Leonardo Da Vinci at some point designed what could be the first in vitro model of a heart valve, 500 years ago! Well, you would say that we have come a long way since then on creating these models. That is arguable. But the truth is that many models today follow the same principle. We certainly now have a greater understanding of how they look and function, and the quest becomes more impassionate everyday. Even though, that is work in progress, a number of people are taking advantage of that knowledge and combine it with biology and engineering to regenerate body tissues and entire organs. I just realized that if given the resources we have today, Da Vinci would have been an amazing tissue engineer. But there is a crucial difference between tissue engineers and Da Vinci, and that is that he was an artist, a philosopher, who viewed life as a whole. Perhaps we need to go back to looking at things in a more complete sense, as Jonah Lehrer suggested in his book “Proust was a neuroscientist.” I think that life is orchestrated by so many different factors, and they complement one another; scientists have forgotten about that. In this blog, I will try to report what the latest advances in the field are, and attempt to analyze where we are going and how close we are to the ultimate goal of reconstructing organs. But most importantly, I will try to make a point that, to make even greater progress, we need the humanities: the arts, the philosophy and a genuine interest to help others.